Authors:

Mayssan Muftah, Kenneth Barshop

Department of Gastroenterology, Chengdu City, China

Abstract:

In eosinophilic esophagitis (EoE), to evaluate the predictive usefulness of baseline peripheral absolute eosinophil counts (AECs) for the proton pump inhibitor (PPI) response. Context : In around 50% of EoE patients, PPI results in histologic remission; nevertheless, there are rarely clinically significant differences. Examine : An adult EoE patient cohort from a tertiary facility between 2012 and 2016 is the subject of this retrospective cohort study. After undergoing twice-daily PPI trials for at least eight weeks, all patients had additional esophageal biopsies, and their histologic response (less than 15 eosinophils/high power field) determined whether they should be classified as PPI-r-EoE or PPI-nr-EoE. Prior to the index endoscopy, baseline peripheral AEC was acquired within a month. Fisher exact/Student t test (univariate) and logistic regression (multivariable) were used for the analyses. Fisher exact/Student t test (univariate) and logistic regression (multivariable) were used for the analyses. Conclusions : In EoE patients, baseline peripheral eosinophilia independently predicts food impaction and PPI nonresponse. Auxiliary.

Keywords:
eosinophilic esophagitis, eosinophil, eosinophilia, proton pump inhibitor, food impaction

Citation:

Kenneth Barshop. Baseline Peripheral Eosinophil Count Independently Predicts Proton Pump Inhibitor Response in Eosinophilic Esophagitis. Japanese Journal of Gastroenterology, 2024.