Correspondence to Author: Harman Singh, Parveen Malhotra, Chitrakshi Bhardwaj, Shivanshu, Himanshu, Rajasvi Khurrana, Sandeep Kumar, Senti. 

Department of Medical Gastroenterology, PGIMS, Rohtak, Haryana, India

DOI: 10.52338/jjogastro.2025.5264

Abstract:

Introduction: Celiac disease has immune based autoimmune disease which is noticed in genetically predisposed persons and is due to gluten allergy. It was initially thought that it is disease of children and presents with typical or classical symptoms associated with gastro-intestinal tract like pain abdomen, diarrhea or constipation. Now, it has been proven that it is commonly seen in adult age also and in half of cases presents with atypical or unclassical symptoms which are mainly due to nutrients or minerals deficiency. Thus, patients can have neurological, psychiatric, dental, reproductive or dermatologic problems. ----- is seen in many cases but in association with celiac disease is rare and very few cases are reported in literature.
Case Report: We report a case of fourty year-old female who presented with pain abdomen and dyspepsia symptoms and on detailed evaluation was found to be having increased serum IgATTG antibody level to 120 I.U./ml. The upper gastro-intestinal endoscopy revealed moderate scalloping of duodenal folds and duodenal biopsy on histopathological examination proved Marsh grade 2 changes. She was started on strict gluten restriction diet and became asymptomatic within six months of gluten restricted diet and her serum IgATTG antibody level also normalized. After a gap of two years, despite on strict gluten restricted diet, she developed atopic dermatitis changes in bilateral hands. She has been on medications by dermatologist but without any substantial relief. Our case is different, in a sense that it was diagnosed two years later after diagnosis of celiac disease, that to on strict gluten restricted diet which led to resolution of primary symptoms of pain abdomen and dyspepsia.
Conclusion: There is a significant association between atopic dermatitis and celiac disease. This association emphasizes the need for timely screening of gastrointestinal morbidities in individuals with atopic dermatitis to prevent long-term complications.

Keywords: Celiac disease, Atopic dermatitis, Dermatitis herpetiformis, Gluten, Serum IgATTG antibody, Endoscopy.

Citation:

Dr. Parveen Malhotra, Dermatological Manifestation in Celiac Disease – An Uncommon Presentation. Japanese Journal of Gastroenterology 2025.