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Is Top-Down Therapy For Crohn’s Disease A Better Option Than Traditional Step-Up Therapy?


Gaurabh Singh

Department of Plastic Surgery, Pondicherry, India

Correspondence to Author:  Gaurabh Singh


The management of Crohn’s malady involves immunological disorder protocols in a very increase approach that progresses through a therapeutic pyramid with many tiers of medication. Medications at the highest ar thought-about strenuous however gift larger risk. a replacement top-down approach to medical aid inverts this procedure, exploitation top-tier medicine for initial treatment. A appraisal of the present literature regarding top-down medical aid was performed to judge its benefit. A literature search was conducted on PubMed, Ovid, and PubMed Central to spot studies of the efficaciousness of top-down medical aid. Papers were appraised critically exploitation the Scottish extramural pointers Network score to judge current proof for the utilization of top-down medical aid. Nineteen studies were known, as well as six irregular controlled trials, 13 cohort studies, and 2 cost-benefit studies. Early combined medical aid involving each biologics and immunomodulators was found to be effective at up patient outcomes; but, early biologics alone weren’t shown to possess a transparent profit over increase medical aid. proof for application in paediatric populations was conjointly inconclusive. The cost-benefit analyses found that top-down medical aid deserves investigation, because it verified to be economical given current information. top-down medical aid has the potential of being a viable various to increase medical aid, however any studies ar required to work out the foremost applicable patients to receive this treatment.

Crohn’s disease, medical treatment, top-down therapy, step-up therapy.


Gaurabh Singh. Is top-down therapy for Crohn’s disease a better option than traditional step-up therapy? Japanese Journal of Gastroenterology 2022.

Journal Info

  • Journal Name: Japanese Journal of Gastroenterology
  • Impact Factor: 2.709**
  • ISSN: 2832-4870
  • DOI: 10.52338/jjogastro
  • Short Name: JJOGASTRO
  • Acceptance rate: 55%
  • Volume: 4 (2024)
  • Submission to acceptance: 25 days
  • Acceptance to publication: 10 days


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  • Rapid Publication
  • Open Access
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