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Proton Pump Inhibitor Use Is Linked To An Increased Incidence Of Pneumonia In Individuals With Cirrhosis: A Systematic Review And Meta-Analysis


Diham Zahi

Department of Physical Medicine & Rehabilitation, Chu ibn rochd Casablanca, Morocco

Correspondence to Author:  Diham Zahi


Background Proton pump inhibitors (PPIs) square measure unremarkably prescribed for cirrhotic patients. However, the employment of PPIs in these patients might increase the danger of microorganism infection. this study aimed to analyze the danger of developing respiratory disease among cirrhotic patients exposed to PPIs. Methods A literature search was severally conducted by a pair of investigators exploitation the phone system and EMBASE databases up to Gregorian calendar month 2019. To be eligible, a study had to be Associate in Nursing empirical (cohort, case-control or cross-sectional) study that enclosed one cluster of cirrhotic patients with PPI use and another cluster of cirrhotic patients while not PPI use. result estimates of the association between PPI use and respiratory disease had to be reported . purpose estimates and customary errors from every eligible study were combined along exploitation the generic inverse variance methodology of DerSimonian and property owner. Results Of 1947 articles known from the two databases, three cohort and five cross-sectional studies with forty,295 participants met the eligibility criteria and were enclosed within the meta-analysis. The pooled analysis found that cirrhotic patients with a history of PPI use had a considerably higher risk of developing respiratory disease than those while not PPI use, with a pooled risk quantitative relation of one.36 (95% confidence interval one.00-1.85; I2 47%).

Pneumonia, proton pump inhibitors, cirrhosis, epidemiology, meta-analysis.


Diham Zahi. Proton pump inhibitor use is linked to an increased incidence of pneumonia in individuals with cirrhosis: a systematic review and meta-analysis Japanese Journal of Gastroenterology 2022.

Journal Info

  • Journal Name: Japanese Journal of Gastroenterology
  • Impact Factor: 2.709**
  • ISSN: 2832-4870
  • DOI: 10.52338/jjogastro
  • Short Name: JJOGASTRO
  • Acceptance rate: 55%
  • Volume: 4 (2024)
  • Submission to acceptance: 25 days
  • Acceptance to publication: 10 days


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