Correspondence to Author: Vani Malhotra, Parveen Malhotra, Rahul Siwach, Pranav Malhotra, Anuj Sharma, Harman Singh, Sandeep Kumar, Senti. 

Department of Medical Gastroenterology, Obstetrics & Gynaecology, PGIMS, Rohtak, Haryana, VMMC & Safdarjung Hospital, New Delhi, India

DOI: 10.52338/jjogastro.2025.5269

Abstract:

Introduction: Hepatitis B poses a significant health problem worldwide. Hepatitis B vaccine as a part of universal immunization, is both costeffective and efficacious with minimal side effects. The reported side effects of the Hepatitis B vaccine include soreness, redness, or swelling at the injection site, headache, fatigue, and a low-grade fever. These are typically mild and resolve within a couple of days. A severe allergic reaction (anaphylaxis) is very rare but possible, with symptoms like hives, swelling, and difficulty breathing occurring shortly after vaccination.
Aim of Study: To determine adverse effects associated with hepatitis B vaccination
Materials & Methods: It was prospective study conducted at Department of Medical Gastroenterology, Post Graduate Institute of Medical Sciences (PGIMS), Rohtak, over a period of five years from 1st October, 2020 to 30th September, 2025. In total, only those five thousand people who got fully vaccinated against hepatitis B by three doses of 20 microgram (1 ml) at 0,1- and 6-months interval, were included in the study. Out of total five thousand participant in study group Out of these five thousand study groups who were hepatitis B negative, 1200 were health care workers, 1000 were HCV patients and 2800 were family members of Hepatitis B patients. Every participant was asked for any kind of adverse side effect, after each dose of HBV vaccination. All participants were above 14 years of age and none was HBV positive.
Results:Out of total five thousand participant in study group, 1200 were health care workers, 1000 were HCV patients and 2800 were family members of Hepatitis B patients. All were given three doses.
Conclusion: Hepatitis B vaccination is devoid of any serious adverse side effects and wherever indicated, complete course should be given on priority.

Keywords: Hepatitis B virus; Hepatitis B Vaccination, Myalgias, Fever, Allergic reaction, Close contact.

Citation:

Dr. Parveen Malhotra, Safety Profile Of Hepatitis B Vaccination. Japanese Journal of Gastroenterology 2025.